Medical Dosimetry
Volume 31, Issue 2 , Pages 152-162 , Summer 2006

The clinical implementation of respiratory-gated intensity-modulated radiotherapy

,Accepted 21 December 2005.

References 

  1. Cancer Facts and Figures 2005, American Cnacer Society. Available at: http://www.cancer.org/downloads/STT/CAFF2005f4PWSecured.pdf. Accessed February 6, 2006.
  2. Machtay M . Higher BED is associated with improved local-regional control and survival for NSCLC treated with chemoradiotherapy (An RTOG analysis) . Int. J. Radiat. Oncol. Biol. Phys. . 2005;63:S66
  3. Martel MK , Ten Haken RK , Hazuka MB , et al.   Estimation of tumor control probability model parameters from 3-D dose distributions of non-small cell lung cancer patients . Lung Cancer . 1999;24(1):31–37
  4. Wulf J , Baier K , Flentje MP . Dose escalation in radiotherapy of lung tumors by stereotactic irradiation (Is there a dose-response relationship for local tumor control?) . Int. J. Radiat. Oncol. Biol. Phys. . 2005;63:S52
  5. McGarry RC , Papiez L , Williams M , et al.   Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma (Phase I study) . Int. J. Radiat. Oncol. Biol. Phys. . 2005;63:1010–1015
  6. Graham MV , Purdy JA , Emami B , et al.   Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC) . Int. J. Radiat. Oncol. Biol. Phys. . 1999;45:323–329
  7. Hernando ML , Marks LB , Bentel GC , et al.   Radiation-induced pulmonary toxicity (a dose-volume histogram analysis in 201 patients with lung cancer) . Int. J. Radiat. Oncol. Biol. Phys. . 2001;51:650–659
  8. Kwa SL , Lebesque JV , Theuws JC , et al.   Radiation pneumonitis as a function of mean lung dose (An analysis of pooled data of 540 patients) . Int. J. Radiat. Oncol. Biol. Phys. . 1998;42:1–9
  9. Oetzel D , Schraube P , Hensley F , et al.   Estimation of pneumonitis risk in three-dimensional treatment planning using dose-volume histogram analysis . Int. J. Radiat. Oncol. Biol. Phys. . 1995;33:455–460
  10. Seppenwoolde Y , Lebesque JV , de Jaeger K , et al.   Comparing different NTCP models that predict the incidence of radiation pneumonitis . Int. J. Radiat. Oncol. Biol. Phys. . 2003;55:724–735
  11. Yorke ED , Jackson A , Rosenzweig KE , et al.   Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy . Int. J. Radiat. Oncol. Biol. Phys. . 2002;54:329–339
  12. Prosnitz RG , Chen YH , Marks LB . Cardiac toxicity following thoracic radiation . Semin. Oncol. . 2005;32:S71–S80
  13. Bradley J , Deasy JO , Bentzen S , et al.   Dosimetric correlates for acute esophagitis in patients treated with radiotherapy for lung carcinoma . Int. J. Radiat. Oncol. Biol. Phys. . 2004;58:1106–1113
  14. Ahn SJ , Kahn D , Zhou S , et al.   Dosimetric and clinical predictors for radiation-induced esophageal injury . Int. J. Radiat. Oncol. Biol. Phys. . 2005;61:335–347
  15. Barnes EA , Murray BR , Robinson DM , et al.   Dosimetric evaluation of lung tumor immobilization using breath hold at deep inspiration . Int. J. Radiat. Oncol. Biol. Phys. . 2001;50:1091–1098
  16. Chen QS , Weinhous MS , Deibel FC , et al.   Fluoroscopic study of tumor motion due to breathing (Facilitating precise radiation therapy for lung cancer patients) . Med.Phys. . 2001;28:1850–1856
  17. Ekberg L , Holmberg O , Wittgren L , et al.   What margins should be added to the clinical target volume in radiotherapy treatment planning for lung cancer? . Radiother. Oncol. . 1998;48:71–77
  18. Erridge SC , Seppenwoolde Y , Muller SH , et al.   Portal imaging to assess set-up errors, tumor motion and tumor shrinkage during conformal radiotherapy of non-small cell lung cancer . Radiother. Oncol. . 2003;66:75–85
  19. Grills IS , Yan D , Martinez AA , et al.   Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer (A comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation) . Int. J. Radiat. Oncol. Biol. Phys. . 2003;57:875–890
  20. Hanley J , Debois MM , Mah D , et al.   Deep inspiration breath-hold technique for lung tumors (The potential value of target immobilization and reduced lung density in dose escalation) . Int. J. Radiat. Oncol. Biol. Phys. . 1999;45:603–611
  21. Murphy MJ , Martin D , Whyte R , et al.   The effectiveness of breath-holding to stabilize lung and pancreas tumors during radiosurgery . Int. J. Radiat. Oncol. Biol. Phys. . 2002;53:475–482
  22. Plathow C , Ley S , Fink C , et al.   Analysis of intrathoracic tumor mobility during whole breathing cycle by dynamic MRI . Int. J. Radiat. Oncol. Biol. Phys. . 2004;59:952–959
  23. Ross CS , Hussey DH , Pennington EC , et al.   Analysis of movement of intrathoracic neoplasms using ultrafast computerized tomography . Int. J. Radiat. Oncol. Biol. Phys. . 1990;18:671–677
  24. Seppenwoolde Y , Shirato H , Kitamura K , et al.   Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy . Int. J. Radiat. Oncol. Biol. Phys. . 2002;53:822–834
  25. Shimizu S , Shirato H , Ogura S , et al.   Detection of lung tumor movement in real-time tumor-tracking radiotherapy . Int. J. Radiat. Oncol. Biol. Phys. . 2001;51:304–310
  26. Stevens CW , Munden RF , Forster KM , et al.   Respiratory-driven lung tumor motion is independent of tumor size, tumor location, and pulmonary function . Int. J. Radiat. Oncol. Biol. Phys. . 2001;51:62–68
  27. Engelsman M , Damen EM , De Jaeger K , et al.   The effect of breathing and set-up errors on the cumulative dose to a lung tumor . Radiother. Oncol. . 2001;60:95–105
  28. Sixel KE , Ruschin M , Tirona R , et al.   Digital fluoroscopy to quantify lung tumor motion (Potential for patient-specific planning target volumes) . Int. J. Radiat. Oncol. Biol. Phys. . 2003;57:717–723
  29. Liu HH , Choi B , Zhang J , et al.   Assessing respiration-induced tumor motion and margin of internal target volume for image-guided radiotherapy of lung cancers . Int. J. Radiat. Oncol. Biol. Phys. . 2005;63:S52
  30. Ling CC , Yorke E , Amols H , et al.   High-tech will improve radiotherapy of NSCLC (A hypothesis waiting to be validated) . Int. J. Radiat. Oncol. Biol. Phys. . 2004;60:3–7
  31. Ramsey CR , Scaperoth D , Arwood D . Clinical efficacy of respiratory gated conformal radiation therapy . Med. Dosim. . 1999;24:115–119
  32. Keall PJ , Kini VR , Vedam SS , et al.   Potential radiotherapy improvements with respiratory gating . Australas. Phys. Eng. Sci. Med. . 2002;25:1–6
  33. Minohara S , Kanai T , Endo M , et al.   Respiratory gated irradiation system for heavy-ion radiotherapy . Int. J. Radiat. Oncol. Biol. Phys. . 2000;47:1097–1103
  34. Ford EC , Mageras GS , Yorke E , et al.   Evaluation of respiratory movement during gated radiotherapy using film and electronic portal imaging . Int. J. Radiat. Oncol. Biol. Phys. . 2002;52:522–531
  35. Ohara K , Okumura T , Akisada M , et al.   Irradiation synchronized with respiration gate . Int. J. Radiat. Oncol. Biol. Phys. . 1989;17:853–857
  36. Vedam SS , Keall PJ , Kini VR , et al.   Determining parameters for respiration-gated radiotherapy . Med. Phys. . 2001;28:2139–2146
  37. Hara R , Itami J , Kondo T , et al.   Stereotactic single high dose irradiation of lung tumors under respiratory gating . Radiother. Oncol. . 2002;63:159–163
  38. Wagman R , Yorke E , Giraud P , et al.   Reproducibility of organ position with respiratory gating for liver tumors (Use in dose-escalation) . Int. J. Radiat. Oncol. Biol. Phys. . 2003;55:659–668
  39. Shen S , Duan J , Fiveash JB , et al.   Validation of target volume and position in respiratory gated CT planning and treatment . Med. Phys. . 2003;30:3196–3205
  40. Duan J , Shen S , Fiveash JB , et al.   Dosimetric effect of respiration-gated beam on IMRT delivery . Med. Phys. . 2003;30:2241–2252
  41. Starkschall G , Forster KM , Kitamura K , et al.   Correlation of gross tumor volume excursion with potential benefits of respiratory gating . Int. J. Radiat. Oncol. Biol. Phys. . 2004;60:1291–1297
  42. Liu HH , Koch N , Starkschall G , et al.   Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI (Part II-margin reduction of internal target volume) . Int. J. Radiat. Oncol. Biol. Phys. . 2004;60:1473–1483
  43. Ramsey CR . Implementation of a Video Based Respiratory Gating System For Radiation Therapy . Knoxville: University of Tennessee; 2000;
  44. Berson AM , Emery R , Rodriguez L , et al.   Clinical experience using respiratory gated radiation therapy (Comparison of free-breathing and breath-hold techniques) . Int. J. Radiat. Oncol. Biol. Phys. . 2004;60:419–426
  45. Yorke E , Rosenzweig KE , Wagman R , et al.   Interfractional anatomic variation in patients treated with respiration-gated radiotherapy . J. Appl. Clin. Med. Phys. . 2005;6:19–32
  46. Hugo GD , Agazaryan N , Solberg TD . The effects of tumor motion on planning and delivery of respiratory-gated IMRT . Med. Phys. . 2003;30:1052–1066
  47. Hugo GD , Agazaryan N , Solberg TD . An evaluation of gating window size, delivery method, and composite field dosimetry of respiratory-gated IMRT . Med. Phys. . 2002;29:2517–2525
  48. Dietrich L , Tucking T , Nill S , et al.   Compensation for respiratory motion by gated radiotherapy (An experimental study) . Phys. Med. Biol. . 2005;50:2405–2414
  49. Chapet O , Thomas E , Kessler ML , et al.   Esophagus sparing with IMRT in lung tumor irradiation (An EUD-based optimization technique) . Int. J. Radiat. Oncol. Biol. Phys. . 2005;63:179–187
  50. Liu HH , Wang X , Dong L , et al.   Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer . Int. J. Radiat. Oncol. Biol. Phys. . 2004;58:1268–1279
  51. Mehta M , Scrimger R , Mackie R , et al.   A new approach to dose escalation in non-small-cell lung cancer . Int. J. Radiat. Oncol. Biol. Phys. . 2001;49:23–33
  52. Murshed H , Liu HH , Liao Z , et al.   Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer . Int. J. Radiat. Oncol. Biol. Phys. . 2004;58:1258–1267
  53. Gambhir SS , Czernin J , Schwimmer J , et al.   A tabulated summary of the FDG PET literature . J. Nucl. Med. . 2001;42:1S–93S
  54. Nehmeh SA , Erdi YE , Ling CC , et al.   Effect of respiratory gating on quantifying PET images of lung cancer . J. Nucl. Med. . 2002;43:876–881
  55. Nehmeh SA , Erdi YE , Ling CC , et al.   Effect of respiratory gating on reducing lung motion artifacts in PET imaging of lung cancer . Med. Phys. . 2002;29:366–371
  56. Nehmeh SA , Erdi YE , Pan T . Four-dimensional (4D) PET/CT imaging of the thorax . Med. Phys. . 2004;31:3179–3186
  57. ICRU . ICRU Report 62. Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50) . Bethesda, MD: International Commission on Radiation Units and Measurements; 1999;
  58. Ahn S , Yi B , Suh Y , et al.   A feasibility study on the prediction of tumour location in the lung from skin motion . Br. J. Radiol. . 2004;77:588–596
  59. Hoisak JD , Sixel KE , Tirona R , et al.   Correlation of lung tumor motion with external surrogate indicators of respiration . Int. J. Radiat. Oncol. Biol. Phys. . 2004;60:1298–1306
  60. Mageras GS , Pevsner A , Yorke ED , et al.   Measurement of lung tumor motion using respiration-correlated CT . Int. J. Radiat. Oncol. Biol. Phys. . 2004;60:933–941
  61. Tsunashima Y , Sakae T , Shioyama Y , et al.   Correlation between the respiratory waveform measured using a respiratory sensor and 3D tumor motion in gated radiotherapy . Int. J. Radiat. Oncol. Biol. Phys. . 2004;60:951–958
  62. Kini VR , Vedam SS , Keall PJ , et al.   Patient training in respiratory-gated radiotherapy . Med Dosim. . 2003;28:7–11
  63. George R , Keall PJ , Chung T , et al.   Does breathing training reduce residual motion for respiratory-gated radiotherapy? . In:  Yi BY ,  Ahn SD ,  Choi EK , et al. editor. The Use of Computers in Radiation Therapy . Seoul, Korea: Jeong Publishing; 2004;p. 437–441
  64. George, R.; Vedam, S.S.; Chung, T.D.; et al. The application of the sinusoidal model to lung cancer patient respiratory motion. Med. Phys. In press.
  65. Senan S , De Ruysscher D , Giraud P , et al.  Radiotherapy Group Of The European Organization For R, Treatment Of C   Literature-based recommendations for treatment planning and execution in high-dose radiotherapy for lung cancer . Radiother. Oncol. . 2004;71:139–146
  66. Bowden P , Fisher R , Mac Manus M , et al.   Measurement of lung tumor volumes using three-dimensional computer planning software . Int. J. Radiat. Oncol. Biol. Phys. . 2002;53:566–573
  67. Giraud P , Elles S , Helfre S , et al.   Conformal radiotherapy for lung cancer (Different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists) . Radiother. Oncol. . 2002;62:27–36
  68. Senan S , van Sornsen de Koste J , Samson M , et al.   Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer . Radiother. Oncol. . 1999;53:247–255
  69. Van de Steene J , Linthout N , de Mey J , et al.   Definition of gross tumor volume in lung cancer (inter-observer variability) . Radiother. Oncol. . 2002;62:37–49
  70. Steenbakkers RJ , Duppen JC , Fitton I , et al.   Observer variation in target volume delineation of lung cancer related to radiation oncologist-computer interaction (a ‘Big Brother’ evaluation) . Radiother. Oncol. . 2005;77(2):182–190
  71. Bradley, J.; Byhardt, R.; Govindan, R.; et al. RTOG 0117: A phase I/II dose intensification study using three-dimensional conformal radiation therapy and concurrent chemotherapy for patients with inoperable, non-small cell lung cancer. Available at: http://www.rtog.org/members/protocols/L0117/0117.pdf. Accessed February 6, 2006.
  72. Giraud P , Antoine M , Larrouy A , et al.   Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning . Int. J. Radiat. Oncol. Biol. Phys. . 2000;48:1015–1024
  73. Kubo HD , Wang L . Compatibility of Varian 2100C gated operations with enhanced dynamic wedge and IMRT dose delivery . Med. Phys. . 2000;27:1732–1738

PII: S0958-3947(05)00198-6

doi: 10.1016/j.meddos.2005.12.002

Medical Dosimetry
Volume 31, Issue 2 , Pages 152-162 , Summer 2006