Medical Dosimetry
Volume 32, Issue 4 , Pages 237-245 , Winter 2007

Intensity-Modulated vs. Conformal Radiotherapy of Parotid Gland Tumors: Potential Impact on Hearing Loss

  • E. Lamers-Kuijper, M.Sc.

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests to: Emmy Lamers-Kuijper, M.Sc., The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Department of Radiation Oncology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
    • ,
  • M. Schwarz, M.Sc.

      Affiliations

    • Agenzia Provinciale per la Protonterapia, Trento, Italy
    • ,
  • C. Rasch, M.D., Ph.D.

      Affiliations

    • Agenzia Provinciale per la Protonterapia, Trento, Italy
    • ,
  • B. Mijnheer, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    • INHOLLAND University of Professional Training, Haarlem, The Netherlands

Received 4 September 2006 ,Accepted 12 December 2006.

References 

  1. Nutting CM, Rowbottom CG, Cosgrove VP, et al. Optimisation of radiotherapy for carcinoma of the parotid gland: A comparison of conventional, three-dimensional conformal, and intensity-modulated techniques. Radiother. Oncol. 2001;60:163–172
  2. Pan CC, Eisbruch A, Lee JS, et al. Prospective study of inner ear radiation dose and hearing loss in head-and-neck cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 2005;61:1393–1402
  3. Johannesen TB, Rasmussen K, Winther FO, et al. Late radiation effects on hearing, vestibular function, and taste in brain tumor patients. Int. J. Radiat. Oncol. Biol. Phys. 2002;53:86–90
  4. Singh IP, Slevin NJ. Late audiovestibular consequences of radical radiotherapy to the parotid. Clin. Oncol. (R. Coll. Radiol.). 1991;3:217–219
  5. Leach W. Irradiation of the ear. J. Laryngol. Otol. 1965;79:870–880
  6. Moretti JA. Sensori-neural hearing loss following radiotherapy to the nasopharynx. Laryngoscope. 1976;86:598–602
  7. Ondrey FG, Greig JR, Herscher L. Radiation dose to otologic structures during head and neck cancer radiation therapy. Laryngoscope. 2000;110:217–221
  8. Keleman G. Experimental defects in the ear and the upper airways induced by radiation. Arch. Otolaryngol. 1955;61:405–418
  9. Evans RA, Liu KC, Azhar T, et al. Assessment of permanent hearing impairment following radical megavoltage radiotherapy. J. Laryngol. Otol. 1988;102:588–589
  10. Anteunis LJ, Wanders SL, Hendriks JJ, et al. A prospective longitudinal study on radiation-induced hearing loss. Am. J. Surg. 1994;168:408–411
  11. Schot LJ, Hilgers FJ, Keus RB, et al. Late effects of radiotherapy on hearing. Eur. Arch. Otorhinolaryngol. 1992;249:305–308
  12. Chen WC, Liao CT, Tsai HC, et al. Radiation-induced hearing impairment in patients treated for malignant parotid tumor. Ann. Otol. Rhinol. Laryngol. 1999;108:1159–1164
  13. Eisbruch A, Kim HM, Terrell JE, et al. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 2001;50:695–704
  14. Eisbruch A, Ship JA, Kim HM, et al. Partial irradiation of the parotid gland. Semin. Radiat. Oncol. 2001;11:234–239
  15. Dias A. Effects on the hearing of patients treated by irradiation in the head and neck area. J. Laryngol. Otol. 1966;80:276–287
  16. Honoré Henriette B, Bentzen SM, M&ooslash;ller K, et al. Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: Individualized risk estimation. Radiother. Oncol. 2002;65:9–16
  17. Nadol JB. Hearing loss. N. Engl. J. Med. 1993;7:1092–1102
  18. Raaijmakers E, Engelen AM. Is sensoneural hearing loss a possible side effect of nasopharyngeal and parotid irradiation? (A systematic review of the literature). Radiother. Oncol. 2002;65:1–7
  19. Jellema AP, Doornaert P, Slotman BJ. Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?. Radiother. Oncol. 2005;77:164–171
  20. Roesink JM, Schipper M, Busschers W, et al. A comparison of mean parotid gland dose with measures of parotid gland function after radiotherapy for head-and-neck cancer: Implications for future trials. Int. J. Radiat. Oncol. Biol. Phys. 2005;63:1006–1007
  21. Braam PM, Roesink JM, Moerland MA, et al. Long-term parotid gland function after radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2005;62:659–664
  22. Thieke C, Bortfeld T, Niemierko A, et al. From physical dose constraints to equivalent uniform dose constraints in inverse radiotherapy planning. Med. Phys. 2003;30:2559–2560
  23. Niemierko A. Reporting and analyzing dose distributions: A concept of equivalent uniform dose. Med. Phys. 1997;24:103–110
  24. ICRU Report 62. Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50). Brussels: International Commission on Radiation Units and Measurements; 1999;
  25. Whimster WF. Biomedical Research. New York: Springer-Verlag, Inc; 1996;

PII: S0958-3947(06)00177-4

doi: 10.1016/j.meddos.2006.12.004

Medical Dosimetry
Volume 32, Issue 4 , Pages 237-245 , Winter 2007

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