Medical Dosimetry
Volume 33, Issue 4 , Pages 259-267 , Winter 2008

Proton Radiotherapy for Liver Tumors: Dosimetric Advantages Over Photon Plans

  • Xiaochun Wang, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
    • Corresponding Author InformationReprint requests to: XiaochunWang, Ph.D., Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 1202, Houston, TX 77030
  • ,
  • Sunil Krishnan, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Xiaodong Zhang, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Lei Dong, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Tina Briere, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Christopher H. Crane, M.D.

      Affiliations

    • Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Mary Martel, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Michael Gillin, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Radhe Mohan, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX
  • ,
  • Sam Beddar, Ph.D.

      Affiliations

    • Department of Radiation Physics, The University of Texas, M. D. Anderson Cancer Center, Houston, TX

Received 26 January 2007 ,Accepted 16 April 2007.

References 

  1. Dawson LA, Normolle D, Balter JM, et al. Analysis of radiation-induced liver disease using the Lyman NTCP model. Int. J. Radiat. Oncol. Biol. Phys. 2002;53:810–821
  2. Cheng JCH, Chuang VP, Cheng SH, et al. Local radiotherapy with or without transcatheter arterial chemoembolization for patients with unresectable hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2000;47:435–442
  3. Robertson JM, Lawrence TS, Andrews JC, et al. Long-term results of hepatic artery fluorodeoxyuridine and conformal radiation therapy for primary hepatobiliary cancers. Int. J. Radiat. Oncol. Biol. Phys. 1997;37:325–330
  4. Park W, Lim DH, Paik SW, et al. Local radiotherapy for patients with unresectable hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2005;61:1143–1150
  5. Cheng JCH, Wu JK, Huang CM, et al. Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:229–234
  6. Park HC, Seong J, Han KH, et al. Dose-response relationship in local radiotherapy for hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2002;54:150–155
  7. Milano MT, Jani AB, Farrey KJ, et al. Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: Toxicity and clinical outcome. Int. J. Radiat. Oncol. Biol. Phys. 2005;63:354–361
  8. Miller DW. A review of proton-beam radiation therapy. Med. Phys. 1995;22:1943–1954
  9. Kawashima M, Furuse J, Nishio T, et al. Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma. J. Clin. Oncol. 2005;23:1839–1846
  10. Chiba T, Tokuuye K, Matsuzaki Y, et al. Proton beam therapy for hepatocellular carcinoma: A retrospective review of 162 patients. Clin. Cancer Res. 2005;11:3799–3805
  11. Gohongi T, Tokuuye K, Lida H, et al. Concurrent proton beam radiotherapy and systemic chemotherapy for the metastatic liver tumor of gastric carcinoma: A case report. Jpn. J. Clin. Oncol. 2005;35:40–44
  12. Bush DA, Hillebrand DJ, Slater JM, et al. High-dose proton beam radiotherapy of hepatocellular carcinoma: Preliminary results of a phase II trial. Gastroenterology. 2004;127:S189–S193
  13. Pan T, Lee TY, Rietzel E, et al. 4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT. Med. Phys. 2004;31:333–340
  14. Ahnesjo A. Collapsed cone convolution of radiant energy for photon dose calculation in heterogeneous media. Med. Phys. 1989;16:577–592
  15. Wu QW, Mohan R. Algorithms and functionality of an intensity modulated radiotherapy optimization system. Med. Phys. 2000;27:701–711
  16. Wu Y, Yan D, Sharpe MB, et al. Implementing multiple static field delivery for intensity modulated beams. Med. Phys. 2001;28:2188–2197
  17. Koehler AM, Schneider RJ, Sisterson JM. Flattening of proton dose distribution for large-field radiotherapy. Med. Phys. 1977;4:297–301
  18. Polf JC, Newhauser WD. Calculations of neutron dose equivalent exposures from range-modulated proton therapy beams. Phys. Med. Biol. 2005;50:3859–3873
  19. Moyers MF, Miller DW, Bush DA, et al. Methodologies and tools for proton beam design for lung tumors. Int. J. Radiat. Oncol. Biol. Phys. 2001;49:1429–1438
  20. Kutcher GJ, Burnman C, Brewster L, et al. Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations. Int. J. Radiat. Oncol. Biol. Phys. 1991;21:137–146
  21. Lyman JT. Complication probability as assessed from dose-volume histogram. Radiat. Res. Suppl. 1985;8:S13–S19
  22. Lawrence TS, Tenhaken RK, Kessler ML, et al. The use of 3D dose-volume analysis to predict radiation hepatitis. Int. J. Radiat. Oncol. Biol. Phys. 1992;23:781–788
  23. Dawson LA, Lawrence TS, Ten Haken RK. Analysis of radiation-induced liver disease using the Lyman NTCP model: In regard to Dawson et al. IJROBP. 2002;53:810–821Response. Int. J. Radiat. Oncol. Biol. Phys. 58:1319–20; 2004
  24. Tenhaken RK, Martel MK, Kessler ML, et al. Use of V(Eff) and Iso-Ntcp in the Implementation of Dose-Escalation Protocols. Int. J. Radiat. Oncol. Biol. Phys. 1993;27:689–695
  25. Lomax AJ, Bortfeld T, Goitein G, et al. A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy. Radiother. Oncol. 1999;51:257–271
  26. Wang H, Dong L, O'Daniel J, et al. Validation of an accelerated ‘demons’ algorithm for deformable image registration in radiation therapy. Phys. Med. Biol. 2005;50:2887–2905
  27. Pan CC, Dawson LA, McGinn CJ, et al. Analysis of radiation induced gastric and duodenal bleeds using the Lyman-Kutcher-Burman Model. Proc. ASTRO. 2003;57:10217
  28. Prosnitz RG, Marks LB. Radiation-induced heart disease: Vigilance is still required. J. Clin. Oncol. 2005;23:7391–7394
  29. Carmel RJ, Kaplan HS. Mantle irradiation in Hodgkins-disease - Analysis of Ttechnique, tumor eradication, and complications. Cancer. 1976;37:2813–2825
  30. Miralbell R, Lomax A, Cella L, et al. Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int. J. Radiat. Oncol. Biol. Phys. 2002;54:824–829
  31. Kang Y, Zhang X, Chang JY, et al. 4D Proton treatment planning strategy for mobile lung tumors. Int. J. Radiat. Oncol. Biol. Phys. 2007;67:906–914
  32. Rosu M, Dawson LA, Balter JM, et al. Alterations in normal liver doses due to organ motion. Int. J. Radiat. Oncol. Biol. Phys. 2003;57:1472–1479

 Supported in part by grant CA74043 from the National Cancer Institute.

PII: S0958-3947(07)00083-0

doi: 10.1016/j.meddos.2007.04.008

Medical Dosimetry
Volume 33, Issue 4 , Pages 259-267 , Winter 2008