Medical Dosimetry
Volume 33, Issue 1 , Pages 48-54 , Spring 2008

Individualized Margins in 3D Conformal Radiotherapy Planning for Lung Cancer: Analysis of Physiological Movements and Their Dosimetric Impacts

Presented in part at the 2004 Canadian Association of Radiation Oncologists Annual Meeting, September 9–12, Halifax, NS, Canada.

  • François Germain, M.D., M.Sc.

      Affiliations

    • Corresponding Author InformationReprint requests to: François Germain, M.D., M.Sc., British Columbia Cancer Agency, Vancouver Island Centre, 2410 Lee Avenue, Victoria, BC, Canada, V8R 6V5.
  • ,
  • Luc Beaulieu, Ph.D.
  • ,
  • André Fortin, M.D., M.Sc.

Received 1 February 2007 ,Accepted 15 May 2007.

References 

  1. American Cancer Society, editor. American Cancer Society. Cancer Facts and Figures 2006. Atlanta; American Cancer Society; 2006.
  2. CCS/NCIC, editor. Canadian Cancer Society/National Cancer Institute of Canada: Canadian Cancer Statistics 2006. Toronto: Canadian Cancer Society; 2006.
  3. Werner-Wasik M, Scott C, Cox JD, et al. Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): Identification of five groups with different survival. Int. J. Radiat. Oncol. Biol. Phys. 2000;48:1475–1482
  4. Lagerwaard FJ, Senan S, van Meerbeeck JP, et al. Has 3-D conformal radiotherapy (3D CRT) improved the local tumour control for stage I non-small cell lung cancer?. Radiother. Oncol. 2002;63:151–157
  5. Balter JM, Ten Haken RK, Lawrence TS, et al. Uncertainties in CT-based radiation therapy treatment planning associated with patient breathing. Int. J. Radiat. Oncol. Biol. Phys. 1996;36:167–174
  6. Giraud P, De Rycke Y, Dubray B, et al. Conformal radiotherapy (CRT) planning for lung cancer: Analysis of intrathoracic organ motion during extreme phases of breathing. Int. J. Radiat. Oncol. Biol. Phys. 2001;51:1081–1092
  7. Minohara S, Endo M, Kanai T, et al. Estimating uncertainties of the geometrical range of particle radiotherapy during respiration. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:121–125
  8. Ruschin M, Sixel KE. Integration of digital fluoroscopy with CT-based radiation therapy planning of lung tumors. Med. Phys. 2002;29:1698–1709
  9. Seppenwoolde Y, Shirato H, Kitamura K, et al. Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2002;53:822–834
  10. Shih HA, Jiang SB, Aljarrah KM, et al. Internal target volume determined with expansion margins beyond composite gross tumor volume in three-dimensional conformal radiotherapy for lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 2004;60:613–622
  11. Shimizu S, Shirato H, Kagei K, et al. Impact of respiratory movement on the computed tomographic images of small lung tumors in three-dimensional (3D) radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2000;46:1127–1133
  12. Yamada K, Soejima T, Minami T, et al. Three-dimensional treatment planning using electrocardiographically gated multi-detector row CT. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:235–239
  13. van Sornsen de Koste JR, Lagerwaard FJ, Nijssen-Visser MR, et al. Tumor location cannot predict the mobility of lung tumors: A 3D analysis of data generated from multiple CT scans. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:348–354
  14. Allen AM, Siracuse KM, Hayman JA, et al. Evaluation of the influence of breathing on the movement and modeling of lung tumors. Int. J. Radiat. Oncol. Biol. Phys. 2004;58:1251–1257
  15. van Sornsen de Koste JR, Lagerwaard FJ, de Boer HC, et al. Are multiple CT scans required for planning curative radiotherapy in lung tumors of the lower lobe?. Int. J. Radiat. Oncol. Biol. Phys. 2003;55:1394–1399
  16. Lagerwaard FJ, van Sornsen de Koste JR, Nijssen-Visser MR, et al. Multiple “slow” CT scans for incorporating lung tumor mobility in radiotherapy planning. Int. J. Radiat. Oncol. Biol. Phys. 2001;51:932–937
  17. Sixel KE, Ruschin M, Tirona R, et al. Digital fluoroscopy to quantify lung tumor motion: Potential for patient-specific planning target volumes. Int. J. Radiat. Oncol. Biol. Phys. 2003;57:717–723
  18. Plathow C, Fink C, Ley S, et al. Measurement of tumor diameter-dependent mobility of lung tumors by dynamic MRI. Radiother. Oncol. 2004;73:349–354
  19. Neicu T, Shirato H, Seppenwoolde Y, et al. Synchronized moving aperture radiation therapy (SMART): Average tumour trajectory for lung patients. Phys. Med. Biol. 2003;48:587–598
  20. Giraud P, Antoine M, Larrouy A, et al. Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning. Int. J. Radiat. Oncol. Biol. Phys. 2000;48:1015–1024
  21. van Sornsen de Koste JR, Lagerwaard FJ, Nijssen-Visser MR, et al. What margins are necessary for incorporating mediastinal nodal mobility into involved-field radiotherapy for lung cancer?. Int. J. Radiat. Oncol. Biol. Phys. 2002;53:1211–1215
  22. McNutt TR, Mackie TR, Reckwerdt P, et al. Calculation of portal dose using the convolution/superposition method. Med. Phys. 1996;23:527–535
  23. Piotrowski T, Matecka-Nowak M, Milecki P. Prediction of radiation pneumonitis: Dose-volume histogram analysis in 62 patients with non-small cell lung cancer after three-dimensional conformal radiotherapy. Neoplasma. 2005;52:56–62
  24. de Boer HC, van Sornsen de Koste JR, Senan S, et al. Analysis and reduction of 3D systematic and random setup errors during the simulation and treatment of lung cancer patients with CT-based external beam radiotherapy dose planning. Int. J. Radiat. Oncol. Biol. Phys. 2001;49:857–868

PII: S0958-3947(07)00109-4

doi: 10.1016/j.meddos.2007.05.003

Medical Dosimetry
Volume 33, Issue 1 , Pages 48-54 , Spring 2008