Medical Dosimetry
Volume 33, Issue 1 , Pages 55-61 , Spring 2008

The Potential for Dose Dumping in Normal Tissues with IMRT for Pelvic and H&N Cancers

Presented in part at the 48th Annual Meeting of the American Association of Physicists in Medicine, July 30–August 3, 2006, Orlando, FL.

  • Nandanuri M.S. Reddy, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY
  • ,
  • Andrzej K. Mazur, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY
  • ,
  • Seshadri Sampath, Ph.D.

      Affiliations

    • Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY
  • ,
  • Adrian Osian, M.S.

      Affiliations

    • Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY
  • ,
  • Brij M. Sood, M.D.

      Affiliations

    • Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY
    • Department of Radiation Oncology, New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, NY
  • ,
  • Akkamma Ravi, M.D.

      Affiliations

    • Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY
    • Department of Radiation Oncology, New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, NY
  • ,
  • Dattatreyudu Nori, M.D., F.A.C.R.

      Affiliations

    • Department of Radiation Oncology, The New York Hospital Queens, Flushing, NY
    • Department of Radiation Oncology, New York Presbyterian Hospital, Weill-Cornell Medical Center, New York, NY
    • Corresponding Author InformationReprint requests to: Dattatreyudu Nori, M.D., F.A.C.R., Department of Radiation Oncology, The New York Hospital Queens, 56-45 Main Street, Flushing, NY.

Received 18 January 2007 ,Accepted 15 May 2007.

References 

  1. Burman C, Chui C-S, Kutcher G, et al. Planning, delivery and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: A strategy for large-scale implementation for the treatment of carcinoma of the prostate. Int. J. Radiat. Oncol. Biol. Phys. 1977;39:863–873
  2. Mohan R, Wu Q, Manning M, et al. Radiobiological considerations in the design of fractionation strategies for intensity modulated radiation therapy of head and neck cancers. Int. J. Radiat. Oncol. Biol. Phys. 2000;46:619–630
  3. Wu Q, Manning M, Schmidt-Ulrich , et al. The potential for sparing of parotid and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers: A treatment design study. Int. J. Radiat. Oncol. Biol. Phys. 2000;46:195–205
  4. Mohan DS, Kupelian PA, Willoughby TR. Short-course intensity-modulated radiotherapy for localized prostate cancer with daily transabdominal ultrasound localization of the prostate gland. Int. J. Radiat. Oncol. Biol. Phys. 2000;46:575–580
  5. Dogan N, King S, Emami B, et al. Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing. Int. J. Radiat. Oncol. Biol. Phys. 2003;57:1480–1491
  6. Galvin JM, Ezzell G, Eisbrach A, et al. Implementing IMRT clinical practice: A joint document of the American Society for Therapeutic Radiology and Oncology and the American Association of Physicists in Medicine. Int. J. Radiat. Oncol. Biol. Phys. 2004;58:1616–1634
  7. Boyer A, Butler , DiPetrillo , et al. Intensity-modulated Rradiotherapy: Current status and issues of interest (Intensity Modulated Radiation Therapy Collaborative Working Group). Int. J. Radiat. Oncol. Biol. Phys. 2001;51:880–914
  8. Ezzell , Galvin JM, Low D, et al. Guidance documentation on delivery, treatment planning, and clinical implementation of IMRT: Report of the IMRT subcommittee of the AAPM radiation therapy committee. Med. Phys. 2003;30:2089–2115
  9. Cheng JC, Wu JK, Huang CM, et al. Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:229–234
  10. Lief EP, DeWyngaert JK, Lymbers SC, et al. Accelerated concomitant boost. Emerging technology. In:  Mundt AJ,  Roeske JC editor. Intensity Modulated Radiation Therapy (A Clinical Perspective). London: BC Decker Inc; 2004;p. 398–406
  11. Scrimger RA, Tome WA, Olivia GH, et al. Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancers, in comparison to conventional field arrangements. Am. J. Clin. Oncol (CCT). 2003;26:70–78
  12. Jackson A, Skwarchuk MW, Zelefsky MJ, et al. Late rectal bleeding after conformal radiotherapy of prostate cancer (II): Volume effects and dose-volume histograms. Int. J. Radiat. Oncol. Biol. Phys. 2001;49:685–698
  13. Fiorino C, Vavassori V, Sanguineti G, et al. Rectum contouring variability in patients treated for prostate cancer: Impact on rectum dose-volume histograms and normal tissue complication probability. Radiother. Oncol. 2002;63:249–255
  14. Foppiano F, Fiorino C, Frezza G, et al. The impact of contouring uncertainty on rectal 3D dose-volume data: Results of a dummy run in a multicenter trial (AIROPROS01-02). Int. J. Radiat. Oncol. Biol. Phys. 2003;57:573–579
  15. Reddy NM, Sood BM, Nori D. Factors influencing the dose to rectum during the treatment of prostate with IMRT. Int. J. Radiat. Oncol. Biol. Phys. 2004;60(Suppl 1):S591;(Abstr)
  16. Reddy N, Sood BM, Mazur A, et al. Comparison of dose to rectum and bladder with 3DCRT and IMRT plans for the treatment of prostate. Med. Phys. 2005;32:1964
  17. Reddy N, Sood BM, Sampath S, et al. Single course IMRT plan to deliver 45 Gy to seminal vesicles and 81 Gy to prostate in 45 fractions. Technol. Cancer Res. Treat. 2006;5:503–512
  18. D’Souza WN, Rosen II. Nontumor integral dose variation in conventional radiotherapy treatment planning. Med. Phys. 2003;30:2065–2071
  19. Hall EJ, Wuu CS. Radiation-induced second cancers: The impact of 3D-CRT and IMRT. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:83–88
  20. Skala M, Holloway L, Bailey M, et al. Australia-wide comparison of intensity modulated radiation therapy prostate plans. Australian Radiol. 2005;49:222–229
  21. Aoyama H, Westerly DC, Mackie TR, et al. Integral radiation dose to normal structures with conformal external beam radiation. Int. J. Radiat. Oncol. Biol. Phys. 2006;64:962–967
  22. Hall EJ. Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int. J. Radiat. Oncol. Biol. Phys. 2006;65:1–7
  23. Coselmon MG, Moran JM, Radawski JD, et al. Improving IMRT delivery efficiency using intensity limits during inverse planning. Med. Phys. 2005;32:1234–1245
  24. Pirzkall A, Carol MP, Pickett B, et al. The effect of beam energy and number of fields on photon-based IMRT for deep-seated targets. Int. J. Radiat. Oncol. Biol. Phys. 2002;53:434–442
  25. Lee N, Chuang C, Quivey JM, et al. Skin toxicity due to intensity-modulated radiotherapy for head-and-neck carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2002;53:630–637
  26. Chao KSC, Ozyigit G, Thorsdad WL. Toxicity profile of intensity-modulated radiation therapy for head and neck carcinoma and potential role of Amifostine. Semin. Oncol. 2003;30:101–108

PII: S0958-3947(07)00110-0

doi: 10.1016/j.meddos.2007.05.001

Medical Dosimetry
Volume 33, Issue 1 , Pages 55-61 , Spring 2008