Medical Dosimetry
Volume 33, Issue 1 , Pages 71-77 , Spring 2008

An imrt technique to increase therapeutic ratio of breast irradiation in patients with early-stage left breast cancer: limiting second malignancies

Received 3 May 2007 ,Accepted 1 October 2007.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer Statistics, 2007. CA Cancer J. Clin. 2007;57:43–66
  2. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N. Engl. J. Med. 2002;347:1233–1241
  3. Poggi MM, Danforth DN, Sciuto LC, et al. Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: The National Cancer Institute Randomized Trial. Cancer. 2003;98:697–702
  4. Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N. Engl. J. Med. 2002;34:1227–1232
  5. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomized trials. Lancet. 2005;366:2087–2106
  6. Bhatnagar AK, Brandner E, Sonnick D, et al. Intensity modulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation: Initial report. Cancer J. 2004;10:381–385
  7. Bhatnagar AK, Brandner E, Sonnick D, et al. Intensity modulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation. Breast Cancer Res. Treat. 2006;96:41–46
  8. Cho BC, Hurkmans CW, Damen EMF, et al. Intensity modulated versus non-intensity modulated radiotherapy in the treatment of the left breast and upper mammary lymph node chain: A comparative planning study. Radiother. Oncol. 2002;62:127–136
  9. Cho BC, Schwarz M, Mijnheer BJ, et al. Simplified intensity modulated radiotherapy using pre-defined segments to reduce cardiac complications in left-sided breast cancer. Radiother. Oncol. 2004;70:231–241
  10. Chui CS, Hong L, Hunt M, et al. A simplified intensity modulation radiation therapy technique for the breast. Med. Phys. 2002;29:522–529
  11. Donovan EM, Bleackley NJ, Evans PM, et al. Dose position and dose volume histogram analysis of standard wedged and intensity modulation treatments in breast radiotherapy. Br. J. Radiol. 2002;75:967–973
  12. Evans PM, Donovan EM, Partridge M, et al. The delivery of intensity modulated radiotherapy to the breast using multiple static fields. Radiother. Oncol. 2000;57:79–89
  13. Fogliata A, Bolsi A, Cozzi L. Critical appraisal of treatment techniques based on conventional photon beams, intensity modulated photon beams and proton beams for therapy of intact breast. Radiother. Oncol. 2002;62:137–145
  14. Goodman KA, Hong L, Wagman R, et al. Dosmetric analysis of a simplified intensity modulated technique for prone breast radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2004;60:95–102
  15. Hurkmans C, Cho BC, Damen E, et al. Reduction of cardiac and lung complication probabilities after breast irradiation using conformal radiotherapy with or without intensity modulation. Radiother. Oncol. 2002;62:163–171
  16. Kestin LL, Sharpe MB, Frazier RC, et al. Intensity modulation to improve dose uniformity with tangential breast radiotherapy: Initial clinical experience. Int. J. Radiat. Oncol. Biol. Phys. 2000;48:1559–1568
  17. Krueger EA, Fraass BA, McShan DL, et al. Potential gains for irradiation of chest wall and regional nodes with intensity modulated radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:1023–1037
  18. Landau D, Adams EJ, Webb S, et al. Cardiac avoidance in breast radiotherapy: A comparison of simple shielding techniques with intensity-modulated radiotherapy. Radiother. Oncol. 2001;60:247–255
  19. Li JG, Williams SS, Goffinet DR, et al. Breast-conserving radiation therapy using combined electron and intensity-modulated radiotherapy technique. Radiother. Oncol. 2000;56:65–71
  20. Li JS, Freedman GM, Price R, et al. Clinical implementation of intensity-modulated tangential beam irradiation for breast cancer. Med. Phys. 2004;31:1023–1031
  21. Ma CM, Ding M, Li JS, et al. A comparative dosimetric study on tangential photon beams, intensity modulated radiation therapy (IMRT) and modulation electron radiotherapy (MERT) for breast cancer treatment. Phys. Med. Biol. 2003;48:909–924
  22. Mayo CS, Urie MM, Fitzgerald TJ. Hybrid IMRT plans—concurrently treating conventional and IMRT beams for improved breast irradiation and reduced planning time. Int. J. Radiat. Oncol. Biol. Phys. 2005;61:922–932
  23. Remouchamps VM, Vicini FA, Sharpe MB, et al. Significant reductions in heart and lung dose using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2003;55:392–406
  24. Thilmann C, Sroka-Perez G, Krempien R, et al. Inversely planned intensity modulated radiotherapy of the breast including the internal mammary chain: A plan comparison study. Technol. Cancer Res. Treat. 2004;3:69–75
  25. Thilmann C, Zabel A, Milker-Zabel S, et al. Number and orientation of beams in inversely planned intensity-modulated radiotherapy of the female breast and the parasternal lymph nodes. Am. J. Clin. Oncol. 2003;26:e136–e143
  26. Thilmann C, Zabel A, Nill S, et al. Intensity-modulated radiotherapy of the female breast. Med. Dosim. 2002;27:79–90
  27. van-Asselen B, Raaijmakers CPJ, Hofman P, et al. An improved breast irradiation technique using three-dimensional geometrical information and intensity modulation. Radiother. Oncol. 2001;58:341–347
  28. Johansson J, Isacsson U, Lindman H, et al. Node-positive left-sided breast cancer patients after breast-conserving surgery: Potential outcomes of radiotherapy modalities and techniques. Radiother. Oncol. 2002;65:89–98
  29. Neal AJ, Torr M, Helyer S, et al. Correlation of breast dose heterogeneity with breast size using 3D CT planning and dose-volume histograms. Radiother. Oncol. 1995;34:210–219
  30. Coles CE, Moody AM, Wilson CB, et al. Reduction of radiotherapy-induced late complications in early breast cancer: The role of intensity modulated radiation therapy and partial breast irradiation. Part II. Radiotherapy strategies to reduce radiation induced late effects. Clin. Oncol. (R. Coll. Radiol.). 2005;17:98–110
  31. Pignol J, Olivotto I, Rakovitch E, et al. Phase III randomized study of intensity modulated radiation therapy versus standard wedging technique for adjuvant breast radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2006;66:S1
  32. Donovan, E.; Bleakley, N.; Denholm, E.; et al. Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother. Oncol. 82:254–64; 2007.
  33. Chang SX, Deschesne KM, Cullip TJ, et al. A comparison of different intensity modulation treatment techniques for tangential breast irradiation. Int. J. Radiat. Oncol. Biol. Phys. 1999;45:1305–1314
  34. Hong L, Hunt M, Chui C, et al. Intensity-modulated tangential beam irradiation of the intact breast. Int. J. Radiat. Oncol. Biol. Phys. 1999;44:1155–1164
  35. Remouchamps VM, Letts N, Vicini FA, et al. Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:704–715
  36. Lo YC, Yasuda G, Fitzgerald TJ, et al. Intensity modulation of breast treatment using static multi-leaf collimators. Int. J. Radiat. Oncol. Biol. Phys. 2000;46:187–194
  37. Vicini F, Sharpe M, Kestin L, et al. Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2002;54:1336–1344
  38. Kutcher GJ, Smith AR, Fowble BL, et al. Treatment planning for primary breast cancer: A patterns of care study. Int. J. Radiat. Oncol. Biol. Phys. 1996;36:733–737
  39. Sollin LJ, Fowble B, Martz KL, et al. Definitive irradiation for early stage breast cancer: The University of Pennsylvania experience. Int. J. Radiat. Oncol. Biol. Phys. 1988;14:235–242
  40. Veronesi U, Zucali R, Luini A. Local control and survival in early breast cancer: The Milan trial. Int. J. Radiat. Oncol. Biol. Phys. 1986;12:717–720
  41. Fisher B, Redmond C, Poisson R, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N. Engl. J. Med. 1989;320:822–828
  42. Lingos TI, Recht A, Vicini F, et al. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 1991;21:355–360
  43. Wallgren A. Late effects of radiotherapy in the treatment of breast cancer. Acta Oncol. 1992;31:237–242
  44. Das IJ, Cheng CW, Fein DA, et al. Patterns of dose variability in radiation prescription of breast cancer. Radiother. Oncol. 1997;44:83–89
  45. Zackrisson B, Arevarn M, Karlsson M. Optimized MLC-beam arrangements for tangential breast irradiation. Radiother. Oncol. 2000;54:209–212
  46. Ragaz J, Olivotto IA, Spinelli JJ, et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J. Natl. Cancer Inst. 2005;97:116–126
  47. Rutqvist LE, Liedberg A, Hammar N, et al. Myocardial infarction among women with early-stage breast cancer treated with conservative surgery and breast irradiation. Int. J. Radiat. Oncol. Biol. Phys. 1998;40:359–363
  48. Nixon AJ, Manola J, Gelman R, et al. No long term increase in cardiac-related mortality after breast-conserving surgery and radiation therapy using modern techniques. J. Clin. Oncol. 1998;16:1374–1379
  49. Gyenes G, Fornander T, Carlens P, et al. Myocardial damage in breast cancer patients treated with adjuvant radiotherapy: A prospective study. Int. J. Radiat. Oncol. Biol. Phys. 1996;36:899–905
  50. Gyenes G, Rutqvist LE, Carlens P, et al. Long-term cardiac morbidity and mortality in a randomized trial of pre- and postoperative radiation therapy versus surgery alone in primary breast cancer. Radiother. Oncol. 1998;48:185–190
  51. Paszat LF, MacKillop WJ, Groome PA, et al. Mortality from myocardial infarction following postlumpectomy radiotherapy for breast cancer: A population-based study in Ontario, Canada. Int. J. Radiat. Oncol. Biol. Phys. 1999;43:755–762
  52. Kuske RR. Adjuvant chest wall and nodal irradiation: Maximize cure, minimize late cardiac toxicity. J. Clin. Oncol. 1998;16:2579–2582
  53. Krueger EA, Fraass BA, Pierce LJ. Clinical aspects of intensity-modulated radiotherapy in the treatment of breast cancer. Semin. Radiat. Oncol. 2002;12:250–259
  54. Bhatnagar AK, Heron DE, Deutsch M, et al. Does breast size affect the scatter dose to the ipsilateral lung, heart, or contralateral breast in primary breast irradiation using intensity-modulated radiation therapy (IMRT)?. Am. J. Clin. Oncol. 2006;29:80–84
  55. Hall EJ, Wuu CS. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:83–88
  56. Kry SF, Salepour M, Followill DS, et al. The calculated risk of total secondary malignances from intensity-modulated radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 2005;62:1195–1203

PII: S0958-3947(07)00158-6

doi: 10.1016/j.meddos.2007.10.001

Medical Dosimetry
Volume 33, Issue 1 , Pages 71-77 , Spring 2008