Medical Dosimetry
Volume 35, Issue 2 , Pages 101-107 , Summer 2010

Incorporating Heterogeneity Correction and 4DCT in Lung Stereotactic Body Radiation Therapy (SBRT): The Effect on Target Coverage, Organ-At-Risk Doses, and Dose Conformity

Presented in part at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Philadelphia, 2006.

  • Kevin N. Franks, M.D.

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • ,
  • Thomas G. Purdie, Ph.D.

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationReprint requests to: Thomas G. Purdie, Ph.D., Department of Radiation Physics, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada
    • ,
  • Laura A. Dawson, M.D.

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Andrea Bezjak, M.D., M.Sc.

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    • ,
  • David A. Jaffray, Ph.D.

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    • Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Jean-Pierre Bissonnette, Ph.D.

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

Received 15 July 2008 ,Accepted 10 March 2009.

References 

  1. Nagata Y, Takayama K, Matsuo Y, et al. Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int. J. Radiat. Oncol. Biol. Phys. 2005;63:1427–1431
  2. Onishi H, Araki T, Shirato H, et al. Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: Clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer. 2004;101:1623–1631
  3. Uematsu M, Shioda A, Suda A, et al. Computed tomography-guided frameless stereotactic radiotherapy for stage I non-small cell lung cancer: a 5-year experience. Int. J. Radiat. Oncol. Biol. Phys. 2001;51:666–670
  4. Timmerman R, Papiez L, McGarry R, et al. Extracranial stereotactic radioablation: Results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest. 2003;124:1946–1955
  5. McGarry RC, Papiez L, Williams M, et al. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: Phase I study. Int. J. Radiat. Oncol. Biol. Phys. 2005;63:1010–1015
  6. RTOG 0236 A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Medically Inoperable Stage I/II Non-Small Cell Lung Cancer. Philadelphia, PA: RTOG; 2006;
  7. Ross CS, Hussey DH, Pennington EC, et al. Analysis of movement of intrathoracic neoplasms using ultrafast computerized tomography. Int. J. Radiat. Oncol. Biol. Phys. 1990;18:671–677
  8. Balter JM, Ten Haken RK, Lawrence TS, et al. Uncertainties in CT-based radiation therapy treatment planning associated with patient breathing. Int. J. Radiat. Oncol. Biol. Phys. 1996;36:167–174
  9. Shimizu S, Shirato H, Kagei KL, et al. Impact of respiratory movement on the computed tomographic images of small lung tumors in three-dimensional (3D) radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2000;46:1127–1133
  10. van der Geld YG, Senan S, van Sornsen de Koste JR, et al. Evaluating mobility for radiotherapy planning of lung tumors: A comparison of virtual fluoroscopy and 4DCT. Lung Cancer. 2006;53:31–37
  11. Underberg RW, Lagerwaard FJ, Cuijpers JP, et al. Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 2004;60:1283–1290
  12. International Commission on Radiation Units and Measurements (ICRU). Report 62: Prescribing, Recording And Reporting Photon Beam Therapy (Supplement to ICRU Report 50). Bethesda, MD: ICRU Publications; 1999;
  13. Purdie TG, Bissonnette JP, Franks K, et al. Cone-beam computed tomography for on-line image guidance of lung stereotactic radiotherapy: Localization, verification, and intrafraction tumor position. Int. J. Radiat. Oncol. Biol. Phys. 2007;68:243–252
  14. Purdie TG, Moseley DJ, Bissonnette JP, et al. Respiration correlated cone-beam computed tomography and 4DCT for evaluating target motion in stereotactic lung radiation therapy. Acta Oncol. 2006;45:915–922
  15. Graham MV, Purdy JA, Emami B, et al. Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int. J. Radiat. Oncol. Biol. Phys. 1999;45:323–329
  16. Feuvret L, Noel G, Mazeron JJ, et al. Conformity index: A review. Int. J. Radiat. Oncol. Biol. Phys. 2006;64:333–342
  17. van't Riet A, Mak AC, Moerland MA, et al. A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: Application to the prostate. In. J. Radiat. Oncol. Biol. Phys. 1997;37:731–736
  18. Butson MJ, Elferink R, Cheung T, et al. Verification of lung dose in an anthropomorphic phantom calculated by the collapsed cone convolution method. Phys. Med. Biol. 2000;45:N143–N149
  19. Bedford JL, Childs PJ, Nordmark Hansen V, et al. Commissioning and quality assurance of the Pinnacle3 radiotherapy treatment planning system for external beam photons. Br. J. Radiol. 2003;76:163–176
  20. Ding GX, Duggan DM, Lu B, et al. Impact of inhomogeneity corrections on dose coverage in the treatment of lung cancer using stereotactic body radiation therapy. Med. Phys. 2007;34:2985–2994
  21. Traberg Hansen A, Petersen JB, Hoyer M, et al. Comparison of two dose calculation methods applied to extracranial stereotactic radiotherapy treatment planning. Radiother. Oncol. 2005;77:96–98
  22. Alvarez PE, Molineu A, Hernandez N, et al. Analysis of multiple irradiations of an anthropomorphic thorax phantom containing lung heterogeneities. Int. J. Radiat. Oncol. Biol. Phys. 2006;66:S685
  23. RTOG 0618 A Phase II Trial of Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Patients with Operable Stage I/II Non-Small Cell Lung Cancer. Philadelphia, PA: RTOG; 2007;
  24. Timmerman R, McGarry R, Yiannoutsos C, et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J. Clin. Oncol. 2006;24:4833–4839
  25. Guckenberger M, Wilbert J, Krieger T, et al. Four-dimensional treatment planning for stereotactic body radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2007;69:276–285
  26. Rosu M, Balter JM, Chetty IJ, et al. How extensive of a 4D dataset is needed to estimate cumulative dose distribution plan evaluation metrics in conformal lung therapy?. Med. Phys. 2007;34:233–245
  27. Shaw E, Kline R, Gillin M, et al. Radiation Therapy Oncology Group: Radiosurgery quality assurance guidelines. Int. J. Radiat. Oncol. Biol. Phys. 1993;27:1231–1239
  28. Lomax NJ, Scheib SG. Quantifying the degree of conformity in radiosurgery treatment planning. Int. J. Radiat. Oncol. Biol. Phys. 2003;55:1409–1419

PII: S0958-3947(09)00013-2

doi: 10.1016/j.meddos.2009.03.007

Medical Dosimetry
Volume 35, Issue 2 , Pages 101-107 , Summer 2010

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