Medical Dosimetry
Volume 36, Issue 1 , Pages 35-40 , Spring 2011

Conkiss: Conformal Kidneys Sparing 3D Noncoplanar Radiotherapy Treatment for Pancreatic Cancer As an Alternative to IMRT

  • Zsolt Sebestyén, M.Sc.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary
    • Corresponding Author InformationReprint requests to: Zsolt Sebestyén, M.Sc., H-7624 Pécs, Édesanyák útja 17, Hungary
  • ,
  • Péter Kovács, M.Sc.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary
  • ,
  • Ákos Gulybán, M.Sc.

      Affiliations

    • EORTC Headquarters, Brussels, Belgium
  • ,
  • Róbert Farkas, M.D.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary
  • ,
  • Szabolcs Bellyei, M.D., Ph.D.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary
  • ,
  • Gábor Liposits, M.D.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary
  • ,
  • András Szigeti, M.D., Ph.D.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary
  • ,
  • Olga Ésik, M.D., D.Sc.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary
  • ,
  • Katalin Dérczy, M.D.

      Affiliations

    • University of Pécs, Department of Radiology, Pécs, Hungary
  • ,
  • László Mangel, M.D., Ph.D.

      Affiliations

    • University of Pécs, Institute of Oncotherapy, Pécs, Hungary

Received 4 June 2009 ,Accepted 10 November 2009.

References 

  1. Brade A, Brierley J, Oza A, et al. Concurrent gemcitabine and radiotherapy with and without neoadjuvant gemcitabine for locally advanced unresectable or resected pancreatic cancer: a phase I-II study. Int. J. Radiat. Oncol. Biol. Phys. 2007;67:1027–1036
  2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA. Cancer. J. Clin. 2008;58:71–96
  3. Ko AH, Quivey JM, Venook AP, et al. A phase II study of fixed-dose rate gemcitabine plus low-dose cisplatin followed by consolidative chemoradiation for locally advanced pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 2007;68:809–816
  4. Keene KS, Rich TA, Penberthy DR, et al. Clinical experience with chronomodulated infusional 5-fluorouracil chemoradiotherapy for pancreatic adenocarcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2005;62:97–103
  5. Murphy JD, Adusumilli S, Griffith KA, et al. Full-dose gemcitabine and concurrent radiotherapy for unresectable pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 2007;68:801–808
  6. Ben-Josef E, Shields AF, Vaishampayan U, et al. Intensity modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 2004;59:454–459
  7. Spry N, Harvey J, MacLeod C, et al. 3D Radiotherapy can be safely combined with sandwich systemic gemcitabine chemotherapy in the management of pancreatic cancer: Actors influencing outcome. Int. J. Radiat. Oncol. Biol. Phys. 2008;70:1438–1446
  8. Dobbs J, Barrett A, Ash D. Practical radiotherapy planning. In: 3rd ed.. Bristol: Arnold and Oxford University Press; 1999;p. 247–252
  9. Brown MW, Ning H, Arora B, et al. A dosimetric analysis of dose escalation using two intensity-modulated radiation therapy techniques in locally advanced pancreatic carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2006;65:274–283
  10. ICRU. Prescribing, recording, and reporting photon beam therapy (Report 50). Bethesda, MD: International Commission on Radiation Units and Measurements; 1993;
  11. ICRU. Prescribing and reporting photon beam therapy (Report 62). Washington D.C: International Commission on Radiation Units and Measurements; 1999;
  12. Wilkowski R, Thoma M, Weingandt H, et al. Chemoradiation for ductal pancreatic carcinoma: Principles of combining chemotherapy with radiation, definition of target volume and radiation dose [review]. JOP. 2005;6:216–230
  13. Dawson LA, Ten Haken RK, Lawrence TS. Partial irradiation of the liver [abstract]. Semin. Radiat. Oncol. 2001;11:240–246
  14. Gulyban Á, Kovács P, Sebestyén Z, et al. Multisegmented tangential breast fields: A rational way to treat breast cancer. Strahlenther. Oncol. 2008;184:262–269
  15. Van't Riet A, Mak AC, Moerland MA, et al. A conformation number to quantify the degree of conformity in brachytherapy and external irradiation: Application to the prostate. Int. J. Radiat. Oncol. Biol. Phys. 1997;37:731–736
  16. Feuvret L, Noël G, Mazeron JJ, et al. Conformity index: A review. Int. J. Radiat. Oncol. Biol. Phys. 2006;64:333–342
  17. Van Asselen B, Raaijmakers CPJ, Hofman P, et al. An improved breast irradiation technique using three-dimensional geometrical information and intensity modulation. Radiother. Oncol. 2001;58:341–347
  18. Hsiung-Stripp DC, McDonough J, Masters HM, et al. Comparative treatment planning between proton and X-ray therapy in pancreatic cancer. Med. Dosim. 2001;26:255–259
  19. Menhel J, Levin D, Alezra D, et al. Assessing the quality of conformal treatment planning: A new tool for quantitative comparison. Phys. Med. Biol. 2006;51:5363–5375
  20. Lomax NJ, Scheib SG. Quantifying the degree of conformity in radiosurgery treatment planning. Int. J. Radiat. Oncol. Biol. Phys. 2003;55:1409–1419
  21. Weber DC, Trofimov AV, Delaney TF, et al. A treatment planning comparison of intensity modulated photon and proton therapy for paraspinal sarcomas. Int. J. Radiat. Oncol. Biol. Phys. 2004;58:1596–1606
  22. Higgins PD, Sohn JW, Fine RM, et al. Three-dimensional conformal pancreas treatment: Comparison of four- to six-field techniques [abstract]. Int. J. Radiat. Oncol. Biol. Phys. 1995;31:605–609
  23. Osborne C, Bydder SA, Ebert MA, et al. Comparison of non-coplanar and coplanar techniques to treat cancer of the pancreas. Australas. Radiol. 2006;50:463–467
  24. Bussels B, Goethals L, Feron M, et al. Respiration-induced movement of the upper abdominal organs: A pitfall for the three-dimensional conformal radiation treatment of pancreatic cancer. Radiother. Oncol. 2003;68:69–74
  25. Gierga DP, Chen GTY, Kung JH, et al. Quantification of respiration-induced abdominal tumor motion and its impact on IMRT dose distributions. Int. J. Radiat. Oncol. Biol. Phys. 2004;58:1584–1595

PII: S0958-3947(09)00127-7

doi: 10.1016/j.meddos.2009.11.001

Medical Dosimetry
Volume 36, Issue 1 , Pages 35-40 , Spring 2011