Abstract
The aim of the study was to investigate the effect of the Hybrid technique which was
created by combining of intensity modulated radiotherapy (IMRT) and volumetric modulated
arc therapy (VMAT) for the treatment of nasopharyngeal cancer (NPC) patients. 7 to
9 field IMRT, triple arc VMAT, and Hybrid plans were generated for 10 advanced stage
NPC patients. The homogeneity index (HI) and the conformity index (CI) of planning
target volumes (PTVs) were calculated for each technique to evaluate the plan quality.
The techniques were compared in terms of plan quality, sparing of organs at risk (OARs),
monitor units (MUs), and delivery time. Hybrid technique significantly improved the
target dose homogeneity and the conformity for PTV70 and PTV60 compared to IMRT and
VMAT. Hybrid plans significantly reduced the maximum dose of the brainstem sparing
compared to the VMAT plans and also improved the sparing of spinal cord compared to
IMRT and VMAT. The MUs and the delivery time of Hybrid plans were found to be between
values for IMRT and VMAT plans. Hybrid technique can be useful when IMRT and VMAT
techniques are not adequate alone in the treatment of NPC patients.
Keywords
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Article info
Publication history
Published online: October 23, 2018
Accepted:
September 24,
2018
Received in revised form:
September 19,
2018
Received:
July 2,
2018
Identification
Copyright
© 2018 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.
