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A retrospective evaluation of mixed energy volumetric modulated arc therapy for anal cancers with lymph node involvement, Eskens et al. 45 (2020): 339-345

      Most modern LINAC are installed with a variety of photon energies varying from 6 MV to 18 MV. The conventional wisdom in external radiotherapy has been that higher energies (>10 MV) are preferred for deep seated pelvic and/or abdominal lesions, especially for larger target volume or larger patients.
      • Laughlin JS
      • Mohan R
      • Kutcher GJ.
      Choice of optimum megavoltage for accelerators for photon beam treatment.
      The usefulness for higher energy is more evident with 3DCRT, as compared to IMRT and VMAT.
      • Soderstrom S
      • Eklof A
      • Brahme A.
      Aspects on the optimal photon beam energy for radiation therapy.
      The recent paper by Eskens et al.
      • Eskens M
      • Nguyen H
      • Deere W
      • et al.
      A retrospective evaluation of mixed energy volumetric modulated arc therapy for anal cancers with lymph node involvement.
      shades more light into the usefulness of using different energies or a combination of energies for anal cancers with lymph node involvement. This is a well written paper; however, certain useful information was not addressed in the manuscript.
      • 1-
        Comparison between 6 MV and 10 MV
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