Abstract
We aimed to evaluate contralateral breast doses calculated with a Treatment Planning
System (TPS) and verified with metal oxide semiconductor field effect transistor (MOSFET)
detectors in patients with early-stage breast cancer (BC) who received helical tomotherapy
(HT) after breast-conserving surgery. The dosimetric data of 30 patients (15 left-sided
and 15 right-sided) with BC treated with 50.4 Gy to the whole breast and 64.4 Gy to
the tumor bed in 28 fractions were analyzed. TPS doses were calculated and MOSFET
doses were measured in the contralateral breast (CB) at cranial, caudal, and midpoint
and 2 cm lateral to the central point. TPS and MOSFET doses were compared in the entire
cohort as well as by tumor location (inner vs outer quadrant) and planning target volume of the breast (<1200 cc vs ≥1200 cc). The average doses at superior, inferior, central, and lateral points calculated
with the TPS were 0.26 ± 0.15 cGy, 0.21 ± 0.09 cGy, 0.65 ± 0.14 cGy, and 0.50 ± 0.11
cGy, respectively, and were 0.37 ± 0.16 cGy, 0.34 ± 0.12 cGy, 0.60 ± 0.18 cGy, and
0.34 ± 0.15 cGy, respectively in MOSFET readings. Except for the central point, TPS-calculated
doses and MOSFET readings were differed. The doses to the CB in patients with inner
and outer quadrant tumors were not significantly different. In patients with large
breasts, MOSFET doses were higher at superior and lateral points than TPS doses, but
TPS doses were greater at inferior points. MOSFET readings were higher than TPS calculated
doses in patients with inner or outer quadrant tumors in small or large breast volumes.
The dose calculated by the TPS and that measured by MOSFET differed by a very small
amount. The maximum dose to the CB administered at the midpoint was 1.8 Gy, as calculated
using the TPS and confirmed using MOSFET detectors, in patients with early-stage BC
undergoing breast-only radiotherapy with HT.
Keywords
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Article info
Publication history
Published online: December 24, 2022
Accepted:
November 30,
2022
Received in revised form:
November 27,
2022
Received:
April 11,
2022
Identification
Copyright
© 2022 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.
