ABSTRACT
This study aimed to compare dosimetric parameters for targets and organs at risk (OARs)
between volumetric modulated arc therapy (VMAT) and automated VMAT (HyperArc, HA)
plans in stereotactic radiotherapy for patients with cervical metastatic spine tumors.
VMAT plans were generated for 11 metastases using the simultaneous integrated boost
technique to deliver 35 to 40 and 20 to 25 Gy for high dose and elective dose planning
target volume (PTVHD and PTVED), respectively. The HA plans were retrospectively generated
using 1 coplanar and 2 noncoplanar arcs. Subsequently, the doses to the targets and
OARs were compared. The HA plans provided significantly higher (p < 0.05) Dmin (77.4 ± 13.1%), D99% (89.3 ± 8.9%), and D98% (92.5 ± 7.7%) for gross tumor volume (GTV) than those of the VMAT plans (73.4 ± 12.2%,
84.2 ± 9.6 and 87.3 ± 8.8% for Dmin, D99% and D98%, respectively). In addition, D99% and D98% for PTVHD were significantly higher in the HA plans, whereas dosimetric parameters
were comparable between the HA and VMAT plans for PTVED. The Dmax values for the brachial plexus, esophagus, and spinal cord were comparable, and no
significant difference was observed in the Dmean for the larynx, pharyngeal constrictor, thyroid, parotid grand (left and right),
and Submandibular gland (left and right). The HA plans provided significantly higher
target coverage of GTV and PTVHD, with a comparable dose for OARs with VMAT plans.
The results of this study may contribute to the improvement of local control in clinical
practice.
Keywords
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References
- Stereotactic ablative radiotherapy for the management of spinal metastases: A review.JAMA Oncol. 2020; 6: 567-577
- Single-fraction radiotherapy versus multifraction radiotherapy for palliation of painful vertebral bone metastases-equivalent efficacy, less toxicity, more convenient: A subset analysis of radiation therapy oncology group trial 97-14.Cancer. 2013; 119: 888-896
- Stereotactic body radiation therapy versus conventional radiation therapy in pain relief for bone metastases: A systematic review and meta-analysis.Int J Radiat Oncol Biol Phys. 2023; 115: 909-921
- Stereotactic body radiotherapy for spinal oligometastases: A review on patient selection and the optimal methodology.Jpn J Radiol. 2022; 40: 1017-1023
- Correlation of local failure with measures of dose insufficiency in the high-dose single-fraction treatment of bony metastases.Int J Radiat Oncol Biol Phys. 2010; 77: 1282-1287
- HyperArc VMAT planning for single and multiple brain metastases stereotactic radiosurgery: A new treatment planning approach.Radiat Oncol. 2018; 13: 13
- Novel strategy with the automatic non-coplanar volumetric-modulated arc therapy for angiosarcoma of the scalp.Radiat Oncol. 2020; 15: 175
- HyperArc VMAT stereotactic radiotherapy for locally recurrent previously-irradiated head and neck cancers: Plan quality, treatment delivery accuracy, and efficiency.J Appl Clin Med Phys. 2022; 23: e13561
- Automated non-coplanar volumetric modulated arc therapy planning for maxillary sinus carcinoma.In Vivo. 2023; 37: 417-423
- Surgical or radiation therapy for the treatment of cervical spine metastases: Results from the Epidemiology, Process, and Outcomes of Spine Oncology (EPOSO) Cohort.Global Spine J. 2020; 10: 21-29
- Management of metastatic cervical spine tumors.J Am Acad Orthop Surg. 2015; 23: 38-46
- Does the region of the spine involved with metastatic tumor affect outcomes of surgical treatments?.World Neurosurg. 2021; 156: e139-e151
- International spine radiosurgery consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.Int J Radiat Oncol Biol Phys. 2012; 83: e597-e605
- The use of a simultaneous integrated boost in spinal stereotactic body radiotherapy to reduce the risk of vertebral compression fractures: a treatment planning study.Acta Oncol. 2018; 57: 1271-1274
- Radiotherapy for unresectable sinonasal cancers: Dosimetric comparison of intensity modulated radiation therapy with coplanar and non-coplanar volumetric modulated arc therapy.Radiother Oncol. 2014; 113: 260-266
- Non-coplanar VMAT plans for postoperative primary brain tumour to reduce dose to hippocampus, temporal lobe and cochlea: A planning study.BJR Open. 2021; 320210009
- Outcomes for spine stereotactic body radiation therapy and an analysis of predictors of local recurrence.Int J Radiat Oncol Biol Phys. 2015; 92: 1016-1026
- Spinal cord dose tolerance to stereotactic body radiation therapy.Int J Radiat Oncol Biol Phys. 2021; 110: 124-136
- Evaluation of inter- and intra-fraction 6D motion for stereotactic body radiation therapy of spinal metastases: Influence of treatment time.Radiat Oncol. 2021; 16: 168
- Residual intra-fraction error in robotic spinal stereotactic body radiotherapy without immobilization devices.Phys Imaging Radiat Oncol. 2020; 16: 20-25
- Comparison of four techniques for spine stereotactic body radiotherapy: Dosimetric and efficiency analysis.J Appl Clin Med Phys. 2018; 19: 160-167
Article info
Publication history
Published online: May 16, 2023
Accepted:
April 4,
2023
Received:
January 24,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.
